Intonation Modeling Using Linguistic, Production and Prosodic Constraints for Syllable based TTS Systems

AbstractThis paper proposes linguistic, production and prosodic constraints for modeling the intonation patterns of sequence of syllables. Linguistic constraints are represented by positional, contextual and phonological features, production constraints are represented by articulatory features, and prosodic constraints are represented by durations and intensities of syllables. Neural network models are explored to capture the implicit intonation knowledge using above mentioned features. The prediction performance of the neural network models is evaluated using objective measures such as average prediction error (μ), standard deviation (σ) and linear correlation coefficient (γX,Y).The prediction performance of the feed-forward neural network (FFNN) models is compared with other statistical models such as Classification and Regression Tree (CART) and Linear Regression (LR) models. The performance of the intonation models is also analyzed by conducting listening tests to evaluate the quality of synthesized speech after incorporating the models in baseline TTS system

IMPACT OF ACTIVE COMPOUNDS ISOLATED FROM BANANA (MUSA SP. VAR. NANJANGUD RASABALE) FLOWER AND PSEUDOSTEM TOWARDS CYTOPROTECTIVE AND DNA PROTECTION ACTIVITIES

Objective: The present study was designed to evaluate for cytoprotective and DNA protective properties of the compounds isolated from ethanol extract of banana flower (EF) and ethanol extract of banana pseudostem (EE).Methods: The four active compounds viz., umbelliferone (C1) andlupeol (C2) from EF and stigmasterol (C3) and β-sitosterol (C4) from EE were isolated by activity-guided repeated fractionation through silica gel column chromatography. The isolated compounds were evaluated for cytoprotective on erythrocytes and pTZ57R/T plasmid DNA protection against hydroxyl radicals.Results: The study revealed that the compounds (C1-C4) at a concentration of 1 mg/ml exhibited 90% protection on erythrocytes membrane oxidation and also protect the pTZ57R/T plasmid DNA damage induced by hydroxyl radicals.Conclusion: These results endorse an insight for a strong chemical basis to the alleged beneï¬cial role of EF and EE in reducing oxidative stress conditions.Â

An Evaluation Framework and Database for MoCap-Based Gait Recognition Methods

As a contribution to reproducible research, this paper presents a framework and a database to improve the development, evaluation and comparison of methods for gait recognition from Motion Capture (MoCap) data. The evaluation framework provides implementation details and source codes of state-of-the-art human-interpretable geometric features as well as our own approaches where gait features are learned by a modification of Fisher's Linear Discriminant Analysis with the Maximum Margin Criterion, and by a combination of Principal Component Analysis and Linear Discriminant Analysis. It includes a description and source codes of a mechanism for evaluating four class separability coefficients of feature space and four rank-based classifier performance metrics. This framework also contains a tool for learning a custom classifier and for classifying a custom query on a custom gallery. We provide an experimental database along with source codes for its extraction from the general CMU MoCap database

Two‐Photon‐Induced CO‐Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells

Phototherapeutic applications of carbon monoxide (CO)‐releasing molecules are limited because they require harmful UV and blue light for activation. We describe two‐photon excitation with NIR light (800 nm)‐induced CO‐release from two MnI tricarbonyl complexes bearing 1,8‐naphthalimide units (1, 2). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single‐ (405 nm) and two‐photon (800 nm) excitation. The photophysical properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chemical calculations. Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light.Metals in Catalysis, Biomimetics & Inorganic Material

The Relationship between Population Structure and Aluminum Tolerance in Cultivated Sorghum

Background: Acid soils comprise up to 50% of the world's arable lands and in these areas aluminum (Al) toxicity impairs root growth, strongly limiting crop yield. Food security is thereby compromised in many developing countries located in tropical and subtropical regions worldwide. In sorghum, SbMATE, an Al-activated citrate transporter, underlies the Alt(SB) locus on chromosome 3 and confers Al tolerance via Al-activated root citrate release. Methodology: Population structure was studied in 254 sorghum accessions representative of the diversity present in cultivated sorghums. Al tolerance was assessed as the degree of root growth inhibition in nutrient solution containing Al. A genetic analysis based on markers flanking Alt(SB) and SbMATE expression was undertaken to assess a possible role for Alt(SB) in Al tolerant accessions. In addition, the mode of gene action was estimated concerning the Al tolerance trait. Comparisons between models that include population structure were applied to assess the importance of each subpopulation to Al tolerance. Conclusion/Significance: Six subpopulations were revealed featuring specific racial and geographic origins. Al tolerance was found to be rather rare and present primarily in guinea and to lesser extent in caudatum subpopulations. Alt(SB) was found to play a role in Al tolerance in most of the Al tolerant accessions. A striking variation was observed in the mode of gene action for the Al tolerance trait, which ranged from almost complete recessivity to near complete dominance, with a higher frequency of partially recessive sources of Al tolerance. A possible interpretation of our results concerning the origin and evolution of Al tolerance in cultivated sorghum is discussed. This study demonstrates the importance of deeply exploring the crop diversity reservoir both for a comprehensive view of the dynamics underlying the distribution and function of Al tolerance genes and to design efficient molecular breeding strategies aimed at enhancing Al tolerance.CGIAR[G3007.04]McKnight FoundationFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)National Council for Scientific and Technological Development (CNPq

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events

Language identification using spectral and prosodic features

This book discusses the impact of spectral features extracted from frame level, glottal closure regions, and pitch-synchronous analysis on the performance of language identification systems. In addition to spectral features, the authors explore prosodic features such as intonation, rhythm, and stress features for discriminating the languages. They present how the proposed spectral and prosodic features capture the language specific information from two complementary aspects, showing how the development of language identification (LID) system using the combination of spectral and prosodic features will enhance the accuracy of identification as well as improve the robustness of the system. This book provides the methods to extract the spectral and prosodic features at various levels, and also suggests the appropriate models for developing robust LID systems according to specific spectral and prosodic features. Finally, the book discuss about various combinations of spectral and prosodic features, and the desired models to enhance the performance of LID systems